What is glycerol-3-phosphate phosphatase (G3PP)?
G3PP activators to counteract overnutrition
G3PP activation to promote healthy aging
Cardiometabolic diseases constitute a major global health challenge. These disorders also contribute to aging-related conditions and geriatric disabilities. Our research, using C. elegans , shows that enhancing G3PP activity promotes healthy aging in these animals and protect from various stresses. This is a particularly interesting avenue of research as aging is a significant risk factor for all cardiometabolic disorders and the WHO has declared 2021-2030 the Decade of Healthy Ageing.